wkio95

Psychedelics paired with therapy could treat chronic mental health conditions Research and Innovation Chronic MDL11939 administration led to a significant 62% increase in 5-HT2A receptor binding in the frontal cortex at 24 hours after the last MDL11939 injection, but there was no change in Kd. Receptor density still remained at 48% above saline control 4 days after the last MDL11939 treatment, but it returned to basal levels between days 4 and 6. Chronic MDL11939 led to a significant enhancement of the conditioned response when animals were tested one day after the last MDL11939 injection. Thus, drug discrimination has been used to define a temporal switch in the nature of the interoceptive cue for LSD, from predominant activation of the 5-HT2A receptor at short times before training to a primary action by stimulation of dopamine D2 receptors at later times after administration. These experiments were described in greater detail in the earlier section on the possible role of other r...