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Psychedelics paired with therapy could treat chronic mental health conditions Research and Innovation Chronic MDL11939 administration led to a significant 62% increase in 5-HT2A receptor binding in the frontal cortex at 24 hours after the last MDL11939 injection, but there was no change in Kd. Receptor density still remained at 48% above saline control 4 days after the last MDL11939 treatment, but it returned to basal levels between days 4 and 6. Chronic MDL11939 led to a significant enhancement of the conditioned response when animals were tested one day after the last MDL11939 injection. Thus, drug discrimination has been used to define a temporal switch in the nature of the interoceptive cue for LSD, from predominant activation of the 5-HT2A receptor at short times before training to a primary action by stimulation of dopamine D2 receptors at later times after administration. These experiments were described in greater detail in the earlier section on the possible role of other r